Microwave Assisted Reactions for Synthesis of Bioactive Azaheterocycles

Abstract

Over the past years, azaheterocycles have received an immense attention because of their notable occurrence in many natural and synthetic drugs, and their large variety of biological activities. In the same time, there is a big need of greener and eco-friendly synthetic approaches in order to respond the actual demands of the changing environment. In this context, the development of more efficient synthetic protocols for azaheterocycles is a big challenge and microwave irradiation represents one of the most effective nonconventional alternatives to the classical methods used in medicinal chemistry. This book chapter presents an overview of the recent advances of microwave assisted reactions and its advantages in synthesis of bioactive 5- and 6-membered ring azaheterocycles (containing one to four nitrogen atoms). Representative considerations regarding mechanistic aspects, differences between conventional and microwave –assisted syntheses and biological activity of the obtained products are discussed.