The “Magic” Zeolites
The “Magic” Zeolites,
21 August 2021
Zeolites amaze us not only with their beauty and their structural variety. Zeolites are also widely used minerals, with different areas of applications. Very important is their feature to work at the cellular level by trapping heavy metals and toxins and safely removing them from the body. Especially Clinoptilolite, a mineral from the Zeolite group is known as one of the most excellent adsorbers. In our study clinoptilolite sorbent KLS–10-MA was applied in a 90-day ecotoxicological experiment with laboratory mice. This sorbent was prepared on the base of natural Bulgarian zeolite. Lead (Pb) was used as toxicant. The animals were arranged in four groups of 60 specimens each: Group 1 (control) – animals fed with conventional food for small rodents and water; Group 2 – animals fed with conventional food + clinosorbent KLS-10-MA and water; Group 3 – animals fed with conventional food and water + Pb(NO3)2; Group 4 – animals fed with conventional food + KLS-10-MA and water + Pb(NO3)2.
Chromosome aberrations, a decrease of the mitotic index, pathological erythrocytes, a drop in the erythropoesis, and a loss of body weight, resulting from a well-expressed toxicological stress, were observed in the Pb-exposed animals.
The dietary inclusion of the clinoptilolite sorbent reduced Pb concentrations in exposed and supplemented mice by 84%, 89%, 91%, 77%, and 88% in carcass, liver, kidneys, bones and feces, respectively. The genetic and physiological parameters of these animals were substantially improved: on day 90 the Pb-exposed and clinoptilolite-supplemented mice exhibited 2.3-fold lower chromosome aberrations frequency, 2.5-fold higher mitotic index, 1.5-fold higher percentage normal erythrocytes, 3.14-fold more proliferating erythrocytes and 1.3-fold higher body weight compared to Pb-exposed and non-supplemented mice. The mitotic index in the supplemented animals increased after day 40.
The sorbent is practically non-toxic and its application is not bad for the animal health and for the environment.
For in-depth study of the kinetics of lead bioaccumulation and of the organism reactions to chronic intoxication, a quantitative approach is also of great importance.
A mathematical model was constructed to outline the common trends of the Pb kinetics in bones. Based on the model, the coefficient of apsorption of Pb by gastrointestinal mucosa in the supplemented mice was found: \(\eta\) = 3.53% . The same coefficient in the non-supplemented animals is \(\eta\) = 15%.
For the first time a mathematical model for the change of the mitotic index with the time was elaborated. This model shows that the recovery processes in the animals run in parallel with the Pb bioaccumulation, and that the susceptibility of the mouse’s organism to Pb load decreases, and the recovery rate of the genetic apparatus increases during the experiment.
In fact zeolites reveal "magical" features and outline realistic perspectives on creating new effective drugs, based on modified natural clinoptilolites, in cases of chronic intoxications.
- cellular level
- Lead intoxication
- Bulgarian zeolite
- Mathematical model
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