Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice

Authors

  • Guijie Li National Citrus Engineering Research Center, Citrus Research Institute, Southwest University, Chongqing, China.
  • Sha Xiang Department of Dermatology, Xinqiao Hospital, Army Medical University, Chongqing, China.
  • Yanni Pan Chongqing University of Education, China.
  • Xingyao Long Chongqing University of Education, China.
  • Yujiao Cheng National Citrus Engineering Research Center, Citrus Research Institute, Southwest University, Chongqing, China.
  • Leng Han National Citrus Engineering Research Center, Citrus Research Institute, Southwest University, Chongqing, China.
  • Xin Zhao Chongqing University of Education, China.

Keywords:

Cold-expression, furocoumarins, coumarins, antioxidant, oxidative stress

Abstract

The aim of this study was to analyze the non-volatile composition and antioxidant differences of lemon essential oils (LEOs) obtained by cold-pressing vs. hydrodistillation. Pathological observations showed that LEO effectively inhibited liver injury caused by oxidative stress, and CPLEO was more effective than HDLEO. CPLEO increased serum T-AOC, SOD, GSH, and GSH-Px levels while decreasing NO, COX-2, IL-6, IL-1\(\beta\), IFN-\(\gamma\), and TNF-\(\alpha\) levels in mice with oxidative damage. The effects of CPLEO were stronger than those of HDLEO and similar to those of vitamin C. CPLEO upregulated mRNA and protein expressions of Cu/Zn-SOD, Mn-SOD, CAT, HO-1, Nrf2, and NQO1 while downregulating nNOS, iNOS, IL-1\(\beta\), COX-2, TNF-\(\alpha\), and NF-kB mRNA expression and nNOS, eNOS, iNOS, and COX-2 protein expression in mice with oxidative damage. The results demonstrate that LEO has good antioxidant effects and that CPLEO has a better antioxidant effect than HDLEO as it retains more active non-volatile substances.

Published

2021-07-29

How to Cite

Guijie Li, Sha Xiang, Yanni Pan, Xingyao Long, Yujiao Cheng, Leng Han, & Xin Zhao. (2021). Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice. Study on Bioactivity of Food and Drug Homologous Products, 105–124. Retrieved from https://stm.bookpi.org/SBFDHP/article/view/2715

Issue

Study on Bioactivity of Food and Drug Homologous Products

Section

Contents