Investigation on the Anti-Ulcerogenic Activity of Aqueous Extract of Unripe Fruit of Musa sapientum Linn in Combination with Vitamin C on Ulcer Induced Models in Experimental Rats

Abstract

Aims: To evaluate the effect of aqueous extract of unripe fruit of Musa sapientum Linn in combination with Vitamin C on aspirin and ethanol induced ulcer models in Wistar rats. It is a tropical plant whose fruit is widely consumed as a nutritious food across the globe.

Study Design: Anti-ulcer study.

Place and Duration of Study: Department of Pharmacology and Therapeutics, Delta State University, Abraka, Delta State, Nigeria, between February and April, 2016.

Methodology: Forty-five rats divided into 9 groups of five were used for each model. Doses of 250 mg/kg, 500 mg/kg, and 1000 mg/kg of Musa sapientum (MS) alone and in combination with Vitamin C 100 mg/kg (1:1) were administered to the animals, Vitamin C 100 mg/kg was administered to another group, while the control group received distilled water. Omeprazole 20 mg/kg was given to a different group. The animals were sacrified and stomach was removed for examination.

Results: The aqueous extract of unripe fruit of Musa sapientum Linn showed significant (P<0.05) decrease in ulcer in both models, which was further enhanced by Vitamin C addition.

Conclusion: This study concludes that Vitamin C potentiates the anti-ulcerogenic effect of unripe fruits of Musa sapientum in rats.