On the Molecular Filters in Cochlea Transduction: A Scientific Explanation
Recent Research Advances in Biology Vol. 6,
3 May 2021
The article is devoted to the specific consideration of the cochlear transduction for the low level sound intensities, which correspond to the regions near the perception threshold. The basic cochlea mechanics is extended by the new concept of the molecular filters, which allows discussing the transduction mechanism on the molecular level in the space?time domain. The molecular filters are supposed to be built on the set of the stereocilia of every inner hair cell. It is hypothesized that the molecular filters are the sensors in the feedback loop, which includes also outer hair cells along with the tectorial membrane and uses the zero compensation method to evaluate the traveling wave shape on the basilar membrane. Besides the compensation, the feedback loop, being spatially distributed along the cochlea, takes control over the tectorial membrane strain field generated by the outer hair cells, and implements it as the mechanism for the automatic gain control in the sound transduction. The numerical simulations of the traveling waves for the real sound intensities also confirm the low values of the basilar membrane deformations.
- molecular filter
- feedback control
- Abstract Viewed: 29 times