New Platelet Concentrates Useful in Tissue Repair. Platelet-rich Fibrin with Leukocytes (L-PRF), Advanced Platelet-Rich Fibrin (A-PRF) and Injectable Platelet-rich Fibrin (i-PRF)
New Platelet Concentrates Useful in Tissue Repair. Platelet-rich Fibrin with Leukocytes (L-PRF), Advanced Platelet-Rich Fibrin (A-PRF) and Injectable Platelet-rich Fibrin (i-PRF),
3 July 2021,
Page 1-54
https://doi.org/10.9734/bpi/mono/978-93-91473-15-0
Growing multidisciplinary field of tissue engineering aims to regenerate, improve or replace predictably damaged or missing tissues for a variety of conditions caused by trauma, disease and old age. To ensure that tissue engineering methods are widely applicable in the clinical setting, it is necessary to modify them in such a way that they are readily available and relatively easy to use in daily clinical routine. Therefore, the steps between preparation and application must be minimized and optimized to make them realistic implementation. General objective of developing platelet concentrates of natural origin, can be produced close to the patient and accelerate the implantation process, being financially realistic for the patient and the health system. Fibrin rich in platelets and leukocytes (PRF) and its derivatives (L-PRF, A-PRF, i-PRF) have been used in a wide variety of medical fields for soft tissue regeneration. Almost all platelets (> 97%) are absent inside test-tubes in groups tested after PRF membrane extraction.
Growth Factors freed by platelets contained in derivatives of L-PRF induce and control the proliferation and migration of other cell types, involved in tissue repair, like smooth cell muscles (SMCs) and mesenchymal stem cells (MSCs).
In conclusion, the results of this work highlight the positive effects of PRF on wound healing after.