ISBN 978-93-91473-15-0 (Print)
ISBN 978-93-91473-20-4 (eBook)
DOI: 10.9734/bpi/mono/978-93-91473-15-0

It was with great pleasure that I accepted the invitation of Dr. Crisci to present this text on the regenerative therapy of lesions, inviting someone to present their own work is always one of the greatest acts of affection and esteem and therefore first of all my thanks for this honor.

It is a text that is characterized by ease of reading, completeness of presentation of the techniques of diagnosis and treatment, order in the different expositions. It is clear from the index that this is a text written by a clinician for clinicians.

There is no lack of evaluation of the latest techniques, research bases and new therapeutic concepts, some of which are still in the experimental phase all aimed at practical application, with the purpose of helping patients.

Initiatives such as this are among the best answers that, those working in the field, can provide.

A vademecum available for doctors, specialists and not; are given the tools to operate at 360 degrees on the problematic centered around the so-called regenerative therapy. The reading is simple but rich in content, combining well the high science with clinical practice, leads to simplify the work of those who approach as a new operator and offers insights to those who are familiar with the practice of this art.

Sharing one's knowledge, one's experience is, I believe, one of the most meritorious of the most meritorious works that can be done. I wish the readers a fruitful reading and the Authors the right and deserved success.

 

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New Platelet Concentrates Useful in Tissue Repair. Platelet-rich Fibrin with Leukocytes (L-PRF), Advanced Platelet-Rich Fibrin (A-PRF) and Injectable Platelet-rich Fibrin (i-PRF)

Alessandro Crisci

New Platelet Concentrates Useful in Tissue Repair. Platelet-rich Fibrin with Leukocytes (L-PRF), Advanced Platelet-Rich Fibrin (A-PRF) and Injectable Platelet-rich Fibrin (i-PRF), 3 July 2021, Page 1-54
https://doi.org/10.9734/bpi/mono/978-93-91473-15-0

Growing multidisciplinary field of tissue engineering aims to regenerate, improve or replace predictably damaged or missing tissues for a variety of conditions caused by trauma, disease and old age. To ensure that tissue engineering methods are widely applicable in the clinical setting, it is necessary to modify them in such a way that they are readily available and relatively easy to use in daily clinical routine. Therefore, the steps between preparation and application must be minimized and optimized to make them realistic implementation. General objective of developing platelet concentrates of natural origin, can be produced close to the patient and accelerate the implantation process, being financially realistic for the patient and the health system. Fibrin rich in platelets and leukocytes (PRF) and its derivatives (L-PRF, A-PRF, i-PRF) have been used in a wide variety of medical fields for soft tissue regeneration. Almost all platelets (> 97%) are absent inside test-tubes in groups tested after PRF membrane extraction.

Growth Factors freed by platelets contained in derivatives of L-PRF induce and control the proliferation and migration of other cell types, involved in tissue repair, like smooth cell muscles (SMCs) and mesenchymal stem cells (MSCs).

In conclusion, the results of this work highlight the positive effects of PRF on wound healing after.