Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents

Authors

  • B. C. Revanasiddappa Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore-575018, (Karnataka), India.
  • E. V. S. Subrahmanyam Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore-575018, (Karnataka), India.

DOI:

https://doi.org/10.9734/bpi/nicb/v2/13095D

Keywords:

1, 3, 4-oxadiazoles, INH, in-vitro’ antibacterial, antifungal

Abstract

In the present investigation a new series of 1, 3, 4-oxadiazoles (3a-j) were synthesized by reacting INH (1) and substituted aromatic acids (2) in presence of POCl3. The new compounds were established on the basis of IR, 1H NMR and Mass spectral data. The compounds were subjected for In-vitro antibacterial and antifungal activities and compared with the standard drugs Some of the tested compounds showed good activity against all the organisms. The presence of electron donating and withdrawing groups at the fourth position is mainly responsible for showing the good activity.

Published

2021-08-26

How to Cite

B. C. Revanasiddappa, & E. V. S. Subrahmanyam. (2021). Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents. New Innovations in Chemistry and Biochemistry Vol. 2, 124–129. https://doi.org/10.9734/bpi/nicb/v2/13095D

Issue

New Innovations in Chemistry and Biochemistry Vol. 2

Section

Chapters