Study on Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-clubbed Chalcone Derivatives

Authors

  • Falguni G. Bhabhor Department of Chemistry, Navjivan Science College, Dahod (GUJ), India.
  • Satish Khadia Department of Chemistry, Navjivan Science College, Dahod (GUJ), India and National medicinal plant board, Ministry of Ayush, New Delhi, India.
  • Harish R. Dabhi Department of Chemistry, Navjivan Science College, Dahod (GUJ), India.

DOI:

https://doi.org/10.9734/bpi/nicb/v2/3660F

Keywords:

2-Mercaptobenzthiazole, chalcone, anti-fungal, anti-bacterial

Abstract

In this present work base catalyzed method used for formation of chalcone of(E)-4-(3-(4-hydroxyphenyl)acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) reacted with derivatives of S-benzo[d]thiol-2yl-2-chloroethanethioate (Ia-f) resulted in formation of corresponding derivatives of  (E)-S-benzo[d]thiazol-2-yl 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl)phenoxy)etanethioate(IIIa-f) was confirmed by spectral characterization such as IR, 1H NMR, LC-MS and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel Gram-positive and Gram-negative bacteria as well as fungi. Compound 3c and 3e shows good activity. All the synthesized compounds were characterized by spectral data.

Published

2021-08-26

How to Cite

Falguni G. Bhabhor, Satish Khadia, & Harish R. Dabhi. (2021). Study on Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-clubbed Chalcone Derivatives. New Innovations in Chemistry and Biochemistry Vol. 2, 117–123. https://doi.org/10.9734/bpi/nicb/v2/3660F

Issue

New Innovations in Chemistry and Biochemistry Vol. 2

Section

Chapters