Greener Buchwald-Hartwig Reaction on Various Heterocycles Using Eucalyptol as Solvent

Authors

  • Joana F. Campos Institut de Chimie Organique et Analytique (ICOA), Université d’Orléans UMR-CNRS 7311, BP 6759, rue de Chartres 45067 Orléans cedex 2, France.
  • Sabine Berteina-Raboin Institut de Chimie Organique et Analytique (ICOA), Université d’Orléans UMR-CNRS 7311, BP 6759, rue de Chartres 45067 Orléans cedex 2, France.

DOI:

https://doi.org/10.9734/bpi/nicb/v2/11775D

Keywords:

Eucalyptol, Buchwald-Hartwig reaction, O,S,N-Heterocycles, Greener methodology, Bio-based solvent

Abstract

We report here the use of eucalyptol as bio-based solvent for Buchwald-Hartwig reaction on various heterocycles. This solvent is interesting on the one hand because it is a non-toxic solvent and on the other hand that its use is a source of development for the consumption of waste from the paper industry that are leaves. These heterocycles containing oxygen, sulfur and nitrogen, which can present interesting therapeutic activities, were chosen as targets or as starting materials in this study. Our objective was to demonstrate that eucalyptol was a possible sustainable alternative to common solvents.

Published

2021-08-26

How to Cite

Joana F. Campos, & Sabine Berteina-Raboin. (2021). Greener Buchwald-Hartwig Reaction on Various Heterocycles Using Eucalyptol as Solvent. New Innovations in Chemistry and Biochemistry Vol. 2, 31–43. https://doi.org/10.9734/bpi/nicb/v2/11775D

Issue

New Innovations in Chemistry and Biochemistry Vol. 2

Section

Chapters