Rediscovering Nifedipine’s Solubility and Redifining Its Rationale of Use in Gynecology

Abstract

The aim of the study is to reinvestigate the solubility property of NIfedipine as a chemical for deeper understanding of its pharmacodynamics and efficacy. Nifedipine is chemically dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, a dihydropyridine derivative used frequently as anti-hypertensive. It is a L- type calcium channel blocker (CCB). There were only a few analogical inconsistencies between Nifedipine's clinical output report and chemical investigation of solubility. By the words of pharmacology books it is a lipophilic substance. But ardent logical question then arises about how being a lipophilic substance it can be used in pregnancy complications like eclampsia and pre-eclampsia without causing any hypotensive crisis in the growing foetus. The ambition of this research is to conduct a re-check and proper quantification of partition co-efficient (logP) of Nifedipine and clarify such discrepancy and rectify if any technical miscalculation during its property verification after discovery. The method used is the “gold standard” shake-flask method followed by analysis using UV-spectrophotometry.