Activity of Some New Substituted Fluoro Benzothiazole Derivatives as Antiepileptics

Abstract

The present study aimed to investigate the antiepileptic activity of fluoro substituted benzothiazole derivatives (FBTDs) in experimental induced epilepsy in mice. The investigation of new antiepileptic drugs is the study of synthetic compounds that may belong to new structural classes and exhibit desirable effects with more beneficial effects than existing drugs. Epilepsy is a tendency to have recurrent seizures. It can affect anyone, at any age, from any walk of life. It is one of the most common serious neurological conditions. The acute oral toxicity was determined as per OECD guideline 423 and minimum effective dose was also determined for pharmacological screening. The antiepileptic activity of FBTDs was studied against maximal electroshock (MES) and strychnine (1 mg/kg, s. c.) induced seizures in mice. In MES test, the duration of tonic hind limb extension was significantly reduced by all FBTDs at a dose of 100 mg/kg except, P-3, and OX-9 whereas in strychnine induced model, the seizure latency was sustained by all FBTDs at a dose of 100 mg/kg except P-4. P-7 and OX-9. The novels synthesized FBTDs exhibit anticonvulsant activity, The ticonvulsant action of FBTDs is better against strychnine induced seizures than MES seizures. P-1, P-2, P5 and P-9 were shown significant anticonvulsant activity against both MES and strychnine induced models.