In recent months, the clinical, scientific, and public health communities have had to respond to new viral genetic variants. Genomic characterization of pandemic isolates of coronavirus 2 has identified viral variants that are less susceptible to neutralization by convalescent plasma, vaccinated plasma/serum, or monoclonal antibodies to SARS-CoV-2 than previous strains. Each has triggered a flurry of media attention, a series of reactions from the scientific community, and calls from governments to "keep calm" or pursue immediate countermeasures. In this book we will try to shed light on the clinical consequences of so many virus mutations, renewing the call for people to maintain safety measures at all times.


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