Key Markers and Epigenetic Modifications of Dental-derived Mesenchymal Stromal Cells: A Review

Authors

  • Jingqiu Chen Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Xiaodan Zheng Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Nanquan Rao a Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Yao Huang Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Juan Liu Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Yanhong Li Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Jun Zhang Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.

DOI:

https://doi.org/10.9734/bpi/etdhr/v4/15654D

Keywords:

Tooth regeneration, Mesenchymal stem cells, Heterogeneity, Marker, Epigenetic regulation

Abstract

The oral region contains a variety of different mesenchymal stromal cells (MSCs) populations. Among the regenerative strategies, dental-derived MSCs based techniques have demonstrated particular promise. Several preclinical studies and clinical trials have been performed using dental-derived MSCs for the treatment of dental and non-dental diseases, such as neurodegenerative diseases, autoimmune and orthopedic disorders. However, dental-derived MSCs exhibit variability among tissues of origin, individual donors, clonal subpopulations, and single cells. Variation in the regenerative potential among cells in dental-derived MSCs cultures may confound trial results and slow or arrest the translation of dental-derived MSCs therapy into clinical practice. Although variation is inevitable, our limited ability to detect and control heterogeneity poses challenges for the production of dental-derived MSCs therapies. Here, we reviewed the heterogeneity of dental-derived MSCs firstly and then discussed the key markers and epigenetic modifications related to the proliferation, differentiation, immunomodulation, and aging of dental-derived MSCs. These messages help to control the composition and function of dental-derived MSCs and thus accelerate the translation of cell therapy into clinical practice.

Published

2022-03-05

How to Cite

Jingqiu Chen, Xiaodan Zheng, Nanquan Rao, Yao Huang, Juan Liu, Yanhong Li, & Jun Zhang. (2022). Key Markers and Epigenetic Modifications of Dental-derived Mesenchymal Stromal Cells: A Review. Emerging Trends in Disease and Health Research Vol. 4, 99–134. https://doi.org/10.9734/bpi/etdhr/v4/15654D

Issue

Emerging Trends in Disease and Health Research Vol. 4

Section

Chapters