Mycobacterial Infection and Activation of Peroxisome Proliferator-Activated Receptors (PPARs): Role of Lipid Accumulation in Infected Cells

Authors

  • Kazunari Tanigawa Department of Molecular Pharmaceutics, Faculty of Pharma-Science, Teikyo University, Itabashi-Ku, Tokyo 173-8605, Japan.
  • Yasuhiro Nakamura Department of Molecular Pharmaceutics, Faculty of Pharma-Science, Teikyo University, Itabashi-Ku, Tokyo 173-8605, Japan.
  • Yuqian Luo Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, Itabashi-Ku, Tokyo 173-8605, Japana and Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
  • Akira Kawashima Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, Itabashi-Ku, Tokyo 173-8605, Japan.
  • Mitsuo Kiriya Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, Itabashi-Ku, Tokyo 173-8605, Japan.
  • Mariko Sugawara-Mikami Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, Itabashi-Ku, Tokyo 173-8605, Japan and  West Yokohama Sugawara Dermatology Clinic, Yokohama, Kanagawa 221-0835, Japan.
  • Ken Karasawa Department of Molecular Pharmaceutics, Faculty of Pharma-Science, Teikyo University, Itabashi-Ku, Tokyo 173-8605, Japan.
  • Koichi Suzuki Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, Itabashi-Ku, Tokyo 173-8605, Japan.

DOI:

https://doi.org/10.9734/bpi/ctcb/v3/6720F

Keywords:

Mycobacteria, M. tuberculosis, M. leprae, PPARs, lipid droplets

Abstract

The present review discusses recent findings that describe the activation of peroxisome proliferator-activated receptors (PPARs) by mycobacterial infections and their role in determining the fate of bacilli by inducing lipid metabolism, anti-inflammatory function, and autophagy. The PPAR-\(\gamma\) activation was mediated by the Middle East respiratory syndrome coronavirus (MERS-CoV)-derived S glycoprotein along with concurrent inhibition of macrophage responses and the suppression of proinflammatory cytokines. The cell wall of mycobacteria is made up of a lot of lipids with different molecular weights. To construct the cellular milieu necessary for their intracellular survival, some mycobacteria species hijack host cells and stimulate lipid droplet production. As a result, lipids are assumed to be critical for mycobacteria survival, invasion, parasitization, and multiplication within host cells. However, their physiological roles have not been fully elucidated. Mycobacteria modulate PPAR signaling and utilize host-derived triacyl-glycerol (TAG) and cholesterol as nutrient sources and for evasion of the host immune system. PPARs are important to the host-dependent mechanism of lipid metabolism and accumulation during mycobacterial infection.

Published

2022-06-30

How to Cite

Kazunari Tanigawa, Yasuhiro Nakamura, Yuqian Luo, Akira Kawashima, Mitsuo Kiriya, Mariko Sugawara-Mikami, … Koichi Suzuki. (2022). Mycobacterial Infection and Activation of Peroxisome Proliferator-Activated Receptors (PPARs): Role of Lipid Accumulation in Infected Cells. Current Topics on Chemistry and Biochemistry Vol. 3, 82–101. https://doi.org/10.9734/bpi/ctcb/v3/6720F

Issue

Current Topics on Chemistry and Biochemistry Vol. 3

Section

Chapters