Determining the Synthesis, Chemical Modification and Biological Properties of N-acylphenothiazines

Authors

  • Iryna Myrko Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska St.69, Lviv 79010, Ukraine.
  • Taras Chaban Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska St.69, Lviv 79010, Ukraine.
  • Yulia Matiichuk Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska St.69, Lviv 79010, Ukraine.
  • Mohammad Arshad College of Medicine, Shaqra University, Al-Dawadmi 11911, Saudi Arabia.
  • Vasyl Matiychuk Department of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodiya St. 6, Lviv 79005, Ukraine.

DOI:

https://doi.org/10.9734/bpi/ctcb/v1/2004B

Keywords:

Synthesis, heterocycles, phenothiazine, N-acylphenothiazines, pharmacological properties

Abstract

Theoretical and experimental data concerning the versatile approaches for the synthesis of N-acylphenothiazines were systematized in this review. The aim of this research was to compile the literature reported worldwide in the past 20 years. The pharmacological effects of these heterocycles as one of the promising chemotherapeutic goals for modern bioorganic and medicinal chemistry were also reviewed in this article. The radical character of the acyl moiety is thought to be responsible for these moieties' immense biological potential. As a result, the current study will make a valuable contribution to the literature and will serve as a springboard for medicinal chemistry experts to conduct additional research focusing on N-acylphenothiazine moieties as potential chemotherapeutic drugs.

Published

2022-04-15

How to Cite

Iryna Myrko, Taras Chaban, Yulia Matiichuk, Mohammad Arshad, & Vasyl Matiychuk. (2022). Determining the Synthesis, Chemical Modification and Biological Properties of N-acylphenothiazines. Current Topics on Chemistry and Biochemistry Vol. 1, 130–147. https://doi.org/10.9734/bpi/ctcb/v1/2004B

Issue

Current Topics on Chemistry and Biochemistry Vol. 1

Section

Chapters