Safety Assessment of POLYSORB® ID a Fatty Acids-Diesters Isosorbide Used as a Plant-based Solutions for Plasticizers

Authors

  • S. Simar-Menti`eres Institut Pasteur de Lille-Laboratoire de Toxicologie G´en´etique, 1 Rue Du Pr. Calmette, Lille Cedex-59019, France.
  • F. Nesslany Institut Pasteur de Lille-Laboratoire de Toxicologie G´en´etique, 1 Rue Du Pr. Calmette, Lille Cedex-59019, France.
  • M. L. Sola ERBC, Chemin de Montifault, Baugy 18800, France.
  • S. Mortier ERBC, Chemin de Montifault, Baugy 18800, France.
  • J. M. Raimbault ERBC, Chemin de Montifault, Baugy 18800, France.
  • F. Gondelle Ineris-Direction des Risques Chroniques, Pˆole VIVA, Unit´e EXES–Parc Technologique ALATA. BP 2, Verneuil-en Halatte-60550, France.
  • L. Chabot Ineris-Direction des Risques Chroniques, Pˆole VIVA, Unit´e EXES–Parc Technologique ALATA. BP 2, Verneuil-en Halatte-60550, France.
  • P. Pandard Ineris-Direction des Risques Chroniques, Pˆole VIVA, Unit´e EXES–Parc Technologique ALATA. BP 2, Verneuil-en Halatte-60550, France.
  • D. Wils Roquette Frères, Toxicology & Safety Unit-Nutrition & Health R&D, 1, Rue de La Haute Loge, Lestrem-62136, France.
  • A. Chentouf Roquette Frères, Toxicology & Safety Unit-Nutrition & Health R&D, 1, Rue de La Haute Loge, Lestrem-62136, France.

DOI:

https://doi.org/10.9734/bpi/ctcb/v1/2834C

Keywords:

POLYSORB® ID 37, isosorbide diester, isosorbide, genotoxicity, mutagenicity, toxicity

Abstract

Phthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications.  These phthalate esters are low toxicity environmental contaminants.  To address these drawbacks, POLYSORB® ID 37, a blend of diesters obtained from esterification of isosorbide with plant-based fatty acids, was developed.  This article will describe the toxicological and biodegradability studies carried out to determine both the human and environmental risk assessments. Overall, all of the toxicological and biodegradability studies demonstrated that POLYSORB® ID 37 is non-toxic to mammalian life and is readily biodegradable.

Published

2022-04-15

How to Cite

S. Simar-Menti`eres, F. Nesslany, M. L. Sola, S. Mortier, J. M. Raimbault, F. Gondelle, … A. Chentouf. (2022). Safety Assessment of POLYSORB® ID a Fatty Acids-Diesters Isosorbide Used as a Plant-based Solutions for Plasticizers . Current Topics on Chemistry and Biochemistry Vol. 1, 65–86. https://doi.org/10.9734/bpi/ctcb/v1/2834C

Issue

Current Topics on Chemistry and Biochemistry Vol. 1

Section

Chapters