Evaluation of Hepatotoxicity of Mallotus Philippensis against CCl4 and ATT-Induced Rats

Abstract

Mallotus philippensis (Mp), also known as kamala in India, is a large woody multipurpose medicinal tree in the Euphorbiaceae family. Mp has many activities, including skin problems, bronchitis, antifungal, worm infestation (tapeworm), eye disease, cancer, diabetes, and diarrhoea. As a result, the current study sought to assess the hepatoprotective potential of Mp methanolic fruit extract. The hepatoprotective activity of CCl4 was investigated using a 1:1 ratio of liquid olive oil to body weight and ATT (isoniazid 7.5 mg/kg, rifampicin 10 mg/kg, and pyrazinamide 35 mg/kg b.w.) induced models. To assess the toxicity, an acute toxicity study and preliminary phytochemical screening were conducted. After oral administration of the methanolic fruits extract at a dose of 2 g/kg body weight, rats showed no toxicity profile. The extract of Mp was given in two doses of 300 mg/kg and 500 mg/kg. Biochemical parameters were reduced significantly (p0.001) when compared to the control. The presence of tannins, alkaloids, flavonoids, saponins, and terpenoids was discovered during phytochemical screening of the fruit extract. It can be concluded that the hepatoprotective activity of Mallotus philippensis is primarily due to the presence of high-value compounds such as the phenolic group, which is the plant's main content.