Study on Enhancement of Anticancer Activity of N(4)1-(2-Pyridyl)piperazinyl 5-Nitroisatin Thiosemicarbazone on Chelation with Copper(II)

Authors

  • Narendra Kumar Singh Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu, Nepal.
  • Smriti Shrestha Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India.
  • Nerina Shahi Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India.
  • Ravinder Kumar Choudhary Department of Chemistry, Gurukula Kangri Vishwavidyalaya, Haridwar-249404, India.
  • Anupa A. Kumbhar Department of Chemistry, Savitribai Phule Pune University, Pune-411007, India.
  • Yuba Raj Pokharel Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India.
  • Paras Nath Yadav Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.

DOI:

https://doi.org/10.9734/bpi/cacs/v9/1762A

Keywords:

Anticancer activity, Copper(II) complex, MDA-MB-231 cell line, 5-Nitroisatin, Thiosemicarbazone

Abstract

The anticancer activity of 5-Nitroisatin-4-(1-(2-pyridyl)piperazinyl)-3-thiosemicarbazone (Nitistpyrdlpz) and its Cu(II) complex against breast cancer cell lines; MCF-7 and MDA-MB-231 and epidermoid carcinoma; A431 showed that the complex contributed to reduce the percentage of cell viability toward all the tested cell lines but remarkable contribution toward MDA-MB-231 cell line. The IC50 values of the complex and free ligand were found in the range of IC50 0.85-1.24 \(\mu\)M and IC50 3.28-3.53 \(\mu\)M, respectively. Among those cell lines, the complex may be the better anticancer agent toward MDA-MB-231 because of its action at micromolar concentration (IC50  0.85 \(\mu\)M).The anticancer potency of ligands can be increased by substitution on parent isatin and pyridyl piperazinyl rings as well as their coordination to metal ions.

Published

2022-04-09

How to Cite

Narendra Kumar Singh, Smriti Shrestha, Nerina Shahi, Ravinder Kumar Choudhary, Anupa A. Kumbhar, Yuba Raj Pokharel, & Paras Nath Yadav. (2022). Study on Enhancement of Anticancer Activity of N(4)1-(2-Pyridyl)piperazinyl 5-Nitroisatin Thiosemicarbazone on Chelation with Copper(II). Challenges and Advances in Chemical Science Vol. 9, 40–55. https://doi.org/10.9734/bpi/cacs/v9/1762A

Issue

Challenges and Advances in Chemical Science Vol. 9

Section

Chapters