The Appropriate Acyclic Precursors to Build Biologically Active 5-acylamino-1,3-thiazoles

Authors

  • Mara Tomassetti Dompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy.
  • Gabriele Lupidi School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.
  • Serena Gabrielli School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.
  • Federico Vittorio Rossi School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.
  • Samuele Lillini Dompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy.
  • Gianluca Bianchini Dompé Farmaceutici S.p.A., Via Campo di Pile, L’Aquila 67100, Italy.
  • Andrea Aramini Dompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy and Dompé Farmaceutici S.p.A., Via Campo di Pile, L’Aquila 67100, Italy.
  • Daniele Canestrari Dompé Farmaceutici S.p.A., Via Campo di Pile, L’Aquila 67100, Italy.
  • Enrico Marcantoni School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.

DOI:

https://doi.org/10.9734/bpi/cacb/v8/9618D

Keywords:

\(\alpha\)-chloroglycinates, 5-acylamino-1,3-thiazoles, Hantzsch reaction

Abstract

The aim of this opinion article is to highlight the trends in the development of efficient catalyst-free synthesis of the Hantzsch polysubstituted 1,3-thiazoles. They are heterocycles of particular importance in the pharmaceutical industry, and the strategy involves the cyclization reaction of acyclic precursors with minimum auxiliary substances, toxic reagents, organic solvents, and disposal problems.

 

Published

2021-06-22

How to Cite

Mara Tomassetti, Gabriele Lupidi, Serena Gabrielli, Federico Vittorio Rossi, Samuele Lillini, Gianluca Bianchini, … Enrico Marcantoni. (2021). The Appropriate Acyclic Precursors to Build Biologically Active 5-acylamino-1,3-thiazoles. Current Advances in Chemistry and Biochemistry Vol. 8, 40–56. https://doi.org/10.9734/bpi/cacb/v8/9618D

Issue

Current Advances in Chemistry and Biochemistry Vol. 8

Section

Chapters