Antimicrobial Activity of Newly Synthesized Thiabendazoles

Authors

  • Siddappa A. Patil Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Kanakapura, Ramanagaram, Bangalore 562112, India.
  • Vikrant Patil Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Kanakapura, Ramanagaram, Bangalore 562112, India.
  • Renukadevi Patil Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
  • Alejandro Bugarin Department of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, FL 33965, USA.
  • Shivaputra A. Patil Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.

DOI:

https://doi.org/10.9734/bpi/cacb/v2/7267D

Keywords:

Thiabendazole, synthesis, characterization, antimicrobial activity, whole cell growth inhibition assays

Abstract

In the present work, three new thiabendazole derivatives (4b and 6a-c) and their intermediates (3a-b) were synthesised by the reaction of inexpensive easily available amines with 4-cyanothiazole in moderate to good yields. The preliminary in vitro antimicrobial evaluation was conducted for all the compounds (3a-b, 4b and 6a-c) by the whole cell growth inhibition assays method towards Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Candida albicans and Cryptococcus neoformansvar. Our research efforts identified the highly potent antibacterial agent 3b which displayed strong growth inhibition (77.12%) towards gram-negative bacteria Acinetobacter baumannii.

Published

2021-02-12

How to Cite

Siddappa A. Patil, Vikrant Patil, Renukadevi Patil, Alejandro Bugarin, & Shivaputra A. Patil. (2021). Antimicrobial Activity of Newly Synthesized Thiabendazoles. Current Advances in Chemistry and Biochemistry Vol. 2, 1–13. https://doi.org/10.9734/bpi/cacb/v2/7267D

Issue

Current Advances in Chemistry and Biochemistry Vol. 2

Section

Chapters