Study on Formulation Development and Characterization of Floating Tablets Using Mentha piperita Extract

Abstract

Objectives: Floating tablets is a novel gastro-retentive drug delivery system which buoyant in stomach and ensure controlled effect. Mentha Piperita is a natural herbal regimen used as carminative, anti-oxidant properties and inhibits gastro-duodenal ulcers disease with increasing mucosal resistance against noxious chemical. Based on the concepts, an objective of present study to develop floating tablets of Mentha Piperita herbal extract used as a medicament for an effective treatment of gastric ulcer.

Methods: Floating tablets containing HPMC K100M and Hibiscus Rosa-sinensis mucilage in different formulations were prepared by direct compression technique and evaluated the relevant parameters.

Results: Depending upon the different ratios, prepared powder blend were subjected to the micromeritic properties which shown good flow characteristics. Prepared tablets were investigated for post-compression parameters and there is no significant variation was observed. Percentage drug content found significant results (90.99±0.15 to 98.53±0.32%) and indicates that, distribution of medicament over an area of floating tablets. From swelling index, F1 formulation has shown highest swelling (78.12%) upto 8h. In-vitro buoyancy studies were found that F1 possess highest floating efficiency (>13 hrs.), lowest floating lag time (0.33±0.1sec) and possesses good buoyancy properties. An in-vitro drug release study shown that, F1 exhibits better controlled release (70.61±0.11%) upto sufficient hours and in-vitro kinetic models were also proven zero order kinetics and medicament release follows Non-Fickian diffusion mechanism.

Conclusions: Developed gastro retentive floating tablets using Mentha piperita extract are more effective for stomach specific drug delivery especially in ulcer disease which suitable for potential therapeutic uses and improves the patient compliance.