Liver Damage due to the Interaction of Malathion with Cimetidine in Rat: Advanced Study

Abstract

In this chapter, we used cimetidine (C) and cimetidine with malathion (M + C) to assess oxidative stress enzymes suggestive of liver damage in rats exposed to malathion (M) in a subchronic form. Cimetidine is a histamine H2-receptor antagonist that has been demonstrated to inhibit many CYP450 isoforms. Malathion, a commonly used organophosphorus insecticide, causes oxidative liver harm. We studied male Wistar rats weighing 200-250 g, exposed to malathion orally for 3 weeks (0.15 mg / kg /day, 2 mg / kg /day, 15 mg / kg /day) and cimetidine 10 mg / kg /day. Malathion affects susceptibility to oxidative stress and possibly    modifies the antioxidant defense capacity directly or indirectly. This study will provide alternate  clinical diagnoses and therapies for pesticide-induced liver illness, as well as focusing future investigations on oxidative stress in organophosphate-exposed patients and creating intervention techniques.