Phytochemical Examination and Hepatoprotective Impact of Stem Bark of Oroxylum indicum (L) Vent. on Carbon Tetrachloride Induced Hepatotoxicity in Rat

Authors

  • Bichitra NandaTripathy Department of Pharmacognosy, Jeypore College of Pharmacy, Rondapalli, Jeypore – 764002, Koraput, Odisha, India.
  • S. K. Panda Department of Pharmacognosy, Jeypore College of Pharmacy, Rondapalli, Jeypore – 764002, Koraput, Odisha, India.
  • S. Sahoo Department of Pharmacognosy, Jeypore College of Pharmacy, Rondapalli, Jeypore – 764002, Koraput, Odisha, India and University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bbsr-751004, Odisha, India.
  • S. K. Mishra Department of Pharmacognosy, Jeypore College of Pharmacy, Rondapalli, Jeypore – 764002, Koraput, Odisha, India and University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bbsr-751004, Odisha, India.
  • L. Nayak Department of Pharmacognosy, Jeypore College of Pharmacy, Rondapalli, Jeypore – 764002, Koraput, Odisha, India and University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bbsr-751004, Odisha, India.

DOI:

https://doi.org/10.9734/bpi/tipr/v3/4069D

Keywords:

Oroxylum indicum (L.), hepatoprotective activity, Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Alkaline Phosphatase (ALP)

Abstract

The study is being carried out to screen and evaluate the hepatoprotective activity of Oroxylum indicum bark extracts (L.)Petroleum ether, chloroform, methanolic, and aqueous extracts of O. indicum were tested for hepatoprotective activity against carbon tetrachloride-induced liver damage in mice using silymarin as a control.The phytochemical content of the extracts was determined.

The enzyme activities of SGOT, SGPT, and ALP (Serum Glutamate Oxaloacetate Transaminase, Serum Glutamate Pyruvate Transaminase, and Alkaline Phosphatase) were investigated. Alcoholi bark extracts of O. indicum showed activity as compared to carbon tetrachloride therapy.

The findings of this study support the conventional use of this plant as a possible hepatoprotective agent.One-way measurement of variance (ANOVA) was used in the statistical analysis, followed by Dunnet's t-test. P-values less than 0.05 were considered significant.

Published

2021-05-12

How to Cite

Bichitra NandaTripathy, S. K. Panda, S. Sahoo, S. K. Mishra, & L. Nayak. (2021). Phytochemical Examination and Hepatoprotective Impact of Stem Bark of Oroxylum indicum (L) Vent. on Carbon Tetrachloride Induced Hepatotoxicity in Rat. Technological Innovation in Pharmaceutical Research Vol. 3, 113–120. https://doi.org/10.9734/bpi/tipr/v3/4069D

Issue

Technological Innovation in Pharmaceutical Research Vol. 3

Section

Chapters