Study on Anti-Diabetic effects of [10]-Gingerol in Streptozotocin and High-Fat Diet-Induced Diabetic Rats

Abstract

This experimental studies showed that its active components [10]-gingerol exert anti-diabetic effects against streptozotocin (STZ) and high-fat-diet (HFD) -induced diabetic rats. The occurrence of type 2 diabetes mellitus is rapidly rising around the world’s population. India is the ‘diabetes capital of the world’ with 62.4 million Indians having type 2 diabetes. The current treatment for type 2 diabetes includes insulin and oral hypoglycemic drugs i.e. sulfonylurea derivatives, thiazolidinediones, biguanides and \(\alpha\)-glucosidase inhibitors but these medications have most of the side effects. Wistar rats (150-200 g) were group housed (n=6) under a standard 12 h light/dark cycle and controlled conditions of temperature and humidity (25±2°C, 55–65%). The histopathological illustration showed normal acini and normal cellular population in the islets of Langerhans in the pancreas of vehicle-treated rats. Our study suggested that [10]-gingerol dose-dependently produced antidiabetic activity. In this study might be helpful to understand the role of [10]-gingerol in the clinical treatment of diabetes mellitus.