Quantitative Estimation Preservative Paraben and Niolone 950 Content in Herbal Skin Unguent

Abstract

A new analytical method was developed and validated for the quantitative estimation of the preservatives, such as Paraben, by High-Performance Liquid Chromatography (HPLC) and Neolone 950 by High- Performance Thin Layer Chromatography (HPTLC), in dermatological unguent [1]. Skin creams typically contain a number of ingredients, including preservatives. The primary reason for including preservatives as antimicrobial additives in skin cream formulations is to protect consumer health and safety. Preservatives are frequently used in multi-component mixtures to broaden the spectrum of antimicrobial properties. 1. Cosmetic product ingredients are labelled in accordance with (European Union) EU legislation. We developed a quantitative method for estimating the preservative concentration in herbal skin cream. The methods described above are based on High-Performance Liquid Chromatography (HPLC) analysis and UV spectroscopy, and they are carried out under various conditions. With minimal sample preparation, the suggested method was applied successfully to the assay of methyl paraben, propyl paraben, and neolone 950 in cosmetic products [2].