Ceftazidime-induced Antibiomania: A Rare Case Study and Review of Literature

Abstract

The aim of this article is to highlight the importance of recognizing the psychiatric side effects of antibiotics early and formulating effective management options to prevent detrimental effects on a patient's clinical condition. Antibiomania is a rare kind of secondary mania caused by antibiotics. We present the first case of antibiomania in a peritoneal dialysis patient caused by ceftazidime, a cephalosporin antibiotic. Manic symptoms were noticed in the patient mentioned here a few days after starting the antibiotic and worsened over the course of a few weeks of antibiotic treatment. In this instance, there is a close correlation between the start of antibiotic treatment and the emergence of manic symptoms.  Antibiotics from various classes have been implicated as the causative agents in a few case reports of antibiomania. Several hypotheses have been proposed regarding the underlying mechanism of antibiomania.