A Brief Overview on microRNA-based Cancer Screening by Blood Test

Abstract

This review article is designed for developing a screening device for breast cancer where early detection can save a life. The use of the miRNA as a biomarker is prevalent in many mature research findings and molecular diagnosis, both of which are quite advanced. Numerous miRNAs have been found to be dysregulated for different types of cancer, according to research on miRNAs and cancer. One technique for measuring the expression of miRNA using molecular beacon probes is real-time PCR. miRNA plays an important role in regulating various genes post-transcriptionally by controlling gene expression levels. miRNAs are found to regulate stem cell differentiation which is important to various organ development. Molecular beacon probes with multiple miRNAs can also be designed to detect multiple disease situations where identified miRNAs exist. Screening high-risk populations for breast cancer is an urgent need, and the technique should be able to reach a large number of people at a low cost.