Research Developments in Medicine and Medical Science Vol. 4

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a liver disorder that affects approximately a quarter of the global population. It is caused by an excess of oxidative stress, inflammation, and abnormal cellular signaling, which can result in liver dysfunction and eventually, carcinoma. Molecular hydrogen has been identified for its specific antioxidant properties and ability to reduce inflammation and regulate cellular activity. In a randomized, double-blind, placebo-controlled trial lasting eight weeks, hydrogen-rich water (HRW) was given to 30 subjects with NAFLD. We noticed favorable trends (p > 0.05) in decreased weight (about 1 kg) and body mass index in the HRW group. HRW was well-tolerated, with no significant changes in liver enzymes and an inclination towards improved lipid profile and lower lactate dehydrogenase levels. HRW tended to decrease nuclear factor kappa B, heat shock protein 70, and matrix metalloproteinase-9 levels non-significantly. Curiously, there was a slight but non-significant increase in the levels of 8-hydroxy-2’-deoxyguanosine and malondialdehyde in the HRW group. This mild increase may suggest hormetic effects of molecular hydrogen. Further, longer-term studies focused on preventing, maintaining, or treating NAFLD and early stages of NASH are required.