Intradialytic Cardiovascular Exercise Training Alters Redox Status, Reduces Inflammation and Improves Physical Performance in End Stage Renal Disease Patients under Hemodialysis

Authors

  • Apostolos Sovatzidis Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Athanasios Chatzinikolaou School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece.
  • Ioannis G. Fatouros School of Physical Education and Sport Sciences, University of Thessaly, Karies, 42100 Trikala, Greece.
  • Stylianos Panagoutsos Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Dimitrios Draganidis School of Physical Education and Sport Sciences, University of Thessaly, Karies, 42100 Trikala, Greece.
  • Eirini Nikolaidou Department of Plastic, Reconstructive and Hand Surgery & Burns ICU, General Hospital of Thessaloniki “G. Papanikolaou”, 57010 Thessaloniki, Greece.
  • Alexandra Avloniti School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece.
  • Yiannis Michailidis School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece.
  • Ioannis Mantzouridis School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece.
  • Alexios Batrakoulis School of Physical Education and Sport Sciences, University of Thessaly, Karies, 42100 Trikala, Greece.
  • Ploumis Pasadakis Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Vassilis Vargemezis Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

DOI:

https://doi.org/10.9734/bpi/rdmmr/v13/14473D

Keywords:

Chronic kidney disease, hemodialysis, exercise, training, oxidative stress, inflammation

Abstract

Introduction: Redox status (RS) perturbations and inflammation are fundamental features of chronic kidney disease (CKD) that are substantially exacerbated in end-stage renal disease (ESRD).

Aim: This study aimed at investigating the efficacy of a 6-month intradialytic exercise training program on RS, inflammation and physical performance in patients with ESRD.

Materials and Methods: Twenty hemodialysis (HD) patients (17 males, 3 females) were randomly assigned to either an intradialytic training (bedside cycling) group (TR; n = 10) or a control group (CON; n = 10) for 6 months. Anthropometrics [body mass and height, body mass index (BMI), body composition], physical performance (VO2peak), functional capacity [North Staffordshire Royal Infirmary (NSRI) walk test, sit-to-stand test (STS-60)], quality of life [(short form-36 (SF-36)] as well as RS [thiobarbituric acid reactive substances (TBARS), protein carbonyls (PC), reduced (GSH) and oxidized (GSSG) glutathione, GSH/GSSG ratio, total antioxidant capacity (TAC), catalase activity (CAT)] and high-sensitivity C-reactive protein (hs-CRP) were assessed at baseline and after the 6-month intervention.

Results: Peak oxygen consumption (VO2peak) increased by 15% only in TR (p < 0.01). Performance in NSRI, STS-60 and SF-36 improved by 4–13% only in TR (p < 0.01). Exercise training reduced TBARS (by 28%), PC (by 31%) and hs-CRP (by 15%), and elevated GSH (by 52%), GSH/GSSG ratio (by 51%), TAC (by 59%) and CAT (by 15%) (p < 0.01).

Conclusion: These findings suggest that engagement in chronic intradialytic cardiovascular exercise alters RS, reduces inflammation and improves performance in patients with ESRD. Future studies are required to examine this scenario using a larger sample size, to allow for the extraction of safe conclusions.

Published

2021-11-24

How to Cite

Apostolos Sovatzidis, Athanasios Chatzinikolaou, Ioannis G. Fatouros, Stylianos Panagoutsos, Dimitrios Draganidis, Eirini Nikolaidou, … Vassilis Vargemezis. (2021). Intradialytic Cardiovascular Exercise Training Alters Redox Status, Reduces Inflammation and Improves Physical Performance in End Stage Renal Disease Patients under Hemodialysis. Recent Developments in Medicine and Medical Research Vol. 13, 29–44. https://doi.org/10.9734/bpi/rdmmr/v13/14473D

Issue

Recent Developments in Medicine and Medical Research Vol. 13

Section

Chapters