Determination of Early T-cell Precursor Acute Lymphoblastic Leukemia- A Neoplasm with Dual Lineage Phenotype

Authors

  • . Surabhi Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.
  • A. Singh Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.
  • J. Singh Nigam Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.

DOI:

https://doi.org/10.9734/bpi/rdmmr/v10/2872E

Keywords:

ETP-ALL, T-ALL, CD1a, CD8

Abstract

Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is a subtype of T-ALL/LBL which is derived from thymic cells at the early T-cell precursor (ETP) differentiation stage that have the potential to differentiate into multiple lineages, including lymphoid and myeloid. ETP-ALL accounts for 15% of childhood T-ALL and 10-30% of adult T-ALL. It has characteristic immunophenotypic expression of CD7, a lack of CD1a and CD8, weak expression of CD5 (with <75% positive blasts), and positive expression of one or more stem cell or myeloid markers including CD117, HLADR, CD13, CD33, CD11b, or CD65.ETP-ALL is identified by a well defined gene expression signature including DNMT3A and FAT3 mutations. We here in report two cases of ETP-ALL with brief review of literature.

Published

2021-10-30

How to Cite

. Surabhi, A. Singh, & J. Singh Nigam. (2021). Determination of Early T-cell Precursor Acute Lymphoblastic Leukemia- A Neoplasm with Dual Lineage Phenotype. Recent Developments in Medicine and Medical Research Vol. 10, 185–191. https://doi.org/10.9734/bpi/rdmmr/v10/2872E

Issue

Recent Developments in Medicine and Medical Research Vol. 10

Section

Chapters