Synthesis of Novel 2,6,9-Trisubstituted Purine Derivatives Coupled with L-Methionine at C2 Position and their Biological Evaluation as Potential Antimicrobial Agent

Abstract

A series of novel 2, 6-diamino-9-methyl purine derivatives coupled with N-Phthaloyl and carboxamide derivatives of L-methionine at the C2 position were synthesized by coupling of 2, 6-diamino-9-methyl purine with N-protected Methionine using phosphorous oxychloride in pyridine. The synthesized compounds were characterized using different physicochemical analyses and IR, ¹H, ¹³C–NMR, MS. The compounds were screened for their in vitro antimicrobial activity and demonstrated significant activity against the tested organisms. These compounds may prove useful as CDK inhibitors.