Preparation of Novel Dihydrophthalazinyl Phenylamide Derivatives and their Anti-Microbial Evaluation

Abstract

Phthalazine derivatives are an essential component of biological systems that serve as a structural template for biologically active molecules. In this chapter, Novel N-(4-(1,2-dihydrophthalazin-1-yl) phenyl) amides were synthesized in good yields, beginning with inexpensive and easily accessible phthalic anhydride using Pd (OAc)₂ catalyzed Suzuki-mayura coupling and N-acylation reactions as key steps. All the prepared compounds were characterized by various spectroscopic techniques such as ¹H NMR, ¹³C NMR, IR, and LCMS and all the data showed good agreement with the predicted structures. Additionally, the produced compounds' in vitro anti-microbial activity was examined. In comparison to Xanthomonas campestris, the target compounds 7i, 7f, and 7a demonstrated superior activity. In contrast, the compounds 7j, 7a, and 7h demonstrated excellent activity against Bacillus megaterium. Escherichia coli was effectively inhibited by compounds 7j and 7a. The obtained N-(4-(1,2-dihydrophthalazin-1-yl) phenyl) amide derivatives offer an intriguing profile in the field of antimicrobial research.