Assessment of In vitro Antimicrobial Activity of Two Different Synthesized Fatty Amides Derivatives against Some Microbial Pathogens: A Recent Study

Abstract

In this present chapter, two amide derivatives with long chains; N-phenyldodecanamide (dodecanilide) 1 and N-cyclohexyloctamide 2 were synthesized and tested in vitro for a wide array of antimicrobial activities against two Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus), four Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella enterica), and three mold fungi (Aspergillus carbonarius, Mucor ramannianus, Candida albicans), to evaluate their potential use as antimicrobial agents. The disc diffusion assay was used to determine the zones of inhibition of these compounds.  The two amides' significant antibacterial activities were indicated by the results. The newly synthesised fatty N-cyclohexyloctamide 2 had antibacterial action against S. aureus and A. carbonarius, and was more effective against C. albicans due to higher zones of inhibition than the previously created fatty anilide 1. Contrarily, the substituted fatty amide 2 was less effective against S. enterica than the fatty anilide 1, which had higher antibacterial activity against P. aeruginosa. Based on these findings, it is feasible to deduce that fatty amide derivatives could be used as disinfection ingredients and as potential sources for new medications that are effective against a variety of infectious diseases.