Improvement of the Manufacturing Process of Active Pharmaceutical Ingredients

Authors

  • A. C. P. Soares Departamento de Engenharia Mecânica, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, R. Dr. António Bernardino de Almeida, 431, 4200-072 Porto, Portugal.
  • R. D. S. G. Campilho Departamento de Engenharia Mecânica, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, R. Dr. António Bernardino de Almeida, 431, 4200-072 Porto, Portugal and INEGI – Pólo FEUP, Rua Dr. Roberto Frias, 400, 4200-465 Porto, Portugal.
  • M.S. Kirgiz Departamento de Engenharia Mecânica, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.
  • M. V. Kumar Department of Civil Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, India.
  • R. Alzein Department of Civil Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, India.

DOI:

https://doi.org/10.9734/bpi/rader/v7/7223A

Keywords:

Pharmaceutical industry, active pharmaceutical ingredients, spray drying, standardization, process improvement, finite element method

Abstract

This work aims to analyze and implement improvements in equipment integrated into production processes in pharmaceutical laboratories for the production of active pharmaceutical ingredients (API). In the project, studies were carried out using the finite element method (FEM) and traditional structural design, to test the feasibility of the selected solutions. Then, the cost analysis was carried out, and the benefits and results of the new equipment were presented. It was possible to conclude that the proposed equipment demonstrates advantages at an ergonomic, hygienic and practical level compared to the original ones, which translates into an increase of the company’s competitiveness in the pharmaceutical market.

Published

2023-08-29

How to Cite

A. C. P. Soares, R. D. S. G. Campilho, M.S. Kirgiz, M. V. Kumar, & R. Alzein. (2023). Improvement of the Manufacturing Process of Active Pharmaceutical Ingredients. Research and Developments in Engineering Research Vol. 7, 16–32. https://doi.org/10.9734/bpi/rader/v7/7223A

Issue

Research and Developments in Engineering Research Vol. 7

Section

Chapters