Cultivation of Bone Marrow Mesenchymal Stromal Cells on Synthetic Polyelectrolyte Nanofilms

Authors

  • Dmitriy A. Reshetnikov Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
  • Maria G. Fomkina Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
  • Lyudmila M. Mezhevikina Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino, Moscow Region, Russia.

DOI:

https://doi.org/10.9734/bpi/rabs/v7/2749A

Keywords:

Polyelectrolytes, nanofilms, mesenchymal stromal cells, culture, adhesion, cell proliferation

Abstract

This study shows the promising use of nanofilms made of synthetic polyelectrolyte materials for effective adhesion and cultivation of animal and human mesenchymal stem cells (MSCs). The features of growth and cytotoxic effects of single-layer and multilayer synthetic films were revealed. It has been shown that the properties of the surface with which these cells are in direct contact during cultivation are of importance for MSCs. The best results of MSC cultivation are achieved on single-layer polyethyleneimine (PEI) films with immobilized growth factors under deprivation conditions, which may be of great importance for cell therapy.

Published

2022-08-24

How to Cite

Dmitriy A. Reshetnikov, Maria G. Fomkina, & Lyudmila M. Mezhevikina. (2022). Cultivation of Bone Marrow Mesenchymal Stromal Cells on Synthetic Polyelectrolyte Nanofilms. Research Aspects in Biological Science Vol. 7, 77–95. https://doi.org/10.9734/bpi/rabs/v7/2749A

Issue

Research Aspects in Biological Science Vol. 7

Section

Chapters