Preparation of Wound Healing Hydrogels Based on Silicon, Iron, Zinc, and Boron Glycerolates: Toxicological Profile, Hemostatic and Antimicrobial Effects

Authors

  • Tat’yana Khonina Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620108 Ekaterinburg, Russia and Soil Science, Agroecology and Chemistry Department, Ural State Agrarian University, 620075 Ekaterinburg, Russia.
  • Semyon Alekseenko Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620108 Ekaterinburg, Russia.
  • Elena Shadrina Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620108 Ekaterinburg, Russia.
  • Il’ya Ganebnykh Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620108 Ekaterinburg, Russia.
  • Alexander Mekhaev Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620108 Ekaterinburg, Russia.
  • Leonid Larionov Pharmacology and Clinical Pharmacology Department, Ural State Medical University, Ministry of Health of the Russian Federation, 620028 Ekaterinburg, Russia.
  • Maria Dobrinskaya Pharmacology and Clinical Pharmacology Department, Ural State Medical University, Ministry of Health of the Russian Federation, 620028 Ekaterinburg, Russia.
  • Nadezhda Izmozherova Pharmacology and Clinical Pharmacology Department, Ural State Medical University, Ministry of Health of the Russian Federation, 620028 Ekaterinburg, Russia.
  • Irina Antropova Pharmacology and Clinical Pharmacology Department, Ural State Medical University, Ministry of Health of the Russian Federation, 620028 Ekaterinburg, Russia.
  • Maxim Karabanalov Institute of New Materials and Technologies, Ural Federal University, 620062 Ekaterinburg, Russia.
  • Muza Kokhan Ural Research Institute for Dermatology, Venereology and Immunopathology, 620076 Ekaterinburg, Russia.
  • Natali’ya Evstigneeva Ural Research Institute for Dermatology, Venereology and Immunopathology, 620076 Ekaterinburg, Russia.
  • Oleg Chupakhin Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620108 Ekaterinburg, Russia and Institute of New Materials and Technologies, Ural Federal University, 620062 Ekaterinburg, Russia.

DOI:

https://doi.org/10.9734/bpi/psnid/v5/5149

Keywords:

Sol–gel processing, silicon, iron(III), zinc, boron glycerolates, nanoscale structure, glycerohydrogel, hemostatic, antimicrobial and wound healing activity

Abstract

Treating wounds and their rapid healing is considered an important topic in ancient and modern research. The use of hydrogels is a promising strategy for achieving hemostasis and wound healing. Sol-gel synthesis is one of the methods for obtaining hydrogels. An innovative direction in sol-gel synthesis is the use of biogenic element polyolates (glycerolates) as biocompatible precursors with a wide range of pharmacological activity. It was shown that hydrogels based on silicon, iron, zinc, and boron glycerolates are non-toxic, and exhibit pronounced hemostatic activity, as well as antimicrobial activity, which is more pronounced for silicon-iron-zinc-boron and silicon-iron-boron glycerolate hydrogels. The results obtained indicate that these glycerolate hydrogels are potential hemostatic and antibiotic-independent antimicrobial agents for topical wound healing applications in medical and veterinary practice.

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Published

2025-04-15

How to Cite

Tat’yana Khonina, Semyon Alekseenko, Elena Shadrina, Il’ya Ganebnykh, Alexander Mekhaev, Leonid Larionov, … Oleg Chupakhin. (2025). Preparation of Wound Healing Hydrogels Based on Silicon, Iron, Zinc, and Boron Glycerolates: Toxicological Profile, Hemostatic and Antimicrobial Effects. Pharmaceutical Science: New Insights and Developments Vol. 5, 108–141. https://doi.org/10.9734/bpi/psnid/v5/5149

Issue

Pharmaceutical Science: New Insights and Developments Vol. 5

Section

Chapters