Method Development and Validation for Simultaneous Estimation of Tapentadol and Paracetamol in the Bulk and Pharmaceutical Dosage Form by UV Spectrophotometry

Authors

  • P. Naresh Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velikatta (Vi.), Kondapak (Mdl) Siddipet (Dist.) Pin – 502277, Telangana (St.), India.
  • Manjunath.S.Yalagatti Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velikatta (Vi.), Kondapak (Mdl) Siddipet (Dist.) Pin – 502277, Telangana (St.), India.
  • V. Padmabhushana Chary Department of Pharmaceutical Analysis, Anurag Pharmacy College, Kodad-508206, Telangana, India.

DOI:

https://doi.org/10.9734/bpi/prrat/v8/3001

Keywords:

0.1N HCl, tapentadol, paracetamol, UV spectrophotometry, simultaneous equation

Abstract

A simple, rapid, accurate and precise UV Spectrophotometric method was developed for the simultaneous estimation of tapentadol (TAP) and paracetamol (PCM) in the pharmaceutical dosage forms. This method utilizes 0.1N hydrochloric acid (HCl) as solvent. Absorption maxima (\(\lambda\)max) of tapentadol and paracetamol was found to be 272.5 nm and 244.0 nm respectively, but we selected 257 nm for paracetamol, because at this wavelength tapentadol is showing linear absorbance values. Linearity was observed in the concentration range of 4-28 µg/ml for both the drugs. The R2 value was found to be 0.9991 and 0.9986 for tapentadol and paracetamol respectively. The method was validated statistically and by recovery studies. The mean percentage recovery was found to be between 95% - 105% for tapentadol and paracetamol.

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Published

2024-11-14

How to Cite

P. Naresh, Manjunath.S.Yalagatti, & V. Padmabhushana Chary. (2024). Method Development and Validation for Simultaneous Estimation of Tapentadol and Paracetamol in the Bulk and Pharmaceutical Dosage Form by UV Spectrophotometry. Pharmaceutical Research: Recent Advances and Trends Vol. 8, 179–196. https://doi.org/10.9734/bpi/prrat/v8/3001

Issue

Pharmaceutical Research: Recent Advances and Trends Vol. 8

Section

Chapters