Epidemiological Characteristics of Carbapenem-Resistant Escherichia coli Clinically Isolated from a Province in Northern China

Authors

  • Wei Zhang Department of Microbiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, People’s Republic of China and Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People’s Republic of China.
  • Zhirong Li Clinical Laboratory, Hebei Provincial Center for Clinical Laboratories, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China.
  • Na Wang Department of Microbiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, People’s Republic of China.
  • Zhicong Yang Department of Microbiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, People’s Republic of China.
  • Jia Li Department of Microbiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, People’s Republic of China.
  • Caiqing Li Department of Microbiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, People’s Republic of China.
  • Xuying Han Department of Microbiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, People’s Republic of China.
  • Jinlu Liu Department of Microbiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, People’s Republic of China.
  • Liping Li Clinical Laboratory, Zhangjiakou Xuan Gang Hospital, Zhangjiakou, Hebei Province, People’s Republic of China.
  • Shuwang Wang Clinical Laboratory, Zhangjiakou Xuan Gang Hospital, Zhangjiakou, Hebei Province, People’s Republic of China.
  • Minghua Zhan Department of Microbiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, People’s Republic of China and Clinical Laboratory, Peking University People’s Hospital, Beijing, People’s Republic of China.

DOI:

https://doi.org/10.9734/bpi/prrat/v7/2282

Keywords:

Enterobacteriales bacteria, multidrug resistance, MIC50/MIC90, regional distribution

Abstract

Purpose: The purpose of the study is to enquire about the epidemiological characteristics of carbapenem-resistant Escherichia coli clinically isolated strains, and to provide data support for treatment and prevention.

Methods: Drug susceptibility testing was performed using the micro-broth dilution method. The drug sensitivity of strains was evaluated using the Clinical and Laboratory Standards Institute (CLSI, 29th edition M100) standards. Data statistical analysis was completed by the WHONET 5.6 software.

Results: Over the three years from 2017 to 2019, a total of 1439 strains of carbapenem-resistant Escherichia coli were isolated. Among them, urine samples accounted for 33.0% and sputum samples accounted for 29.8%, ranking the top two. Male patients accounted for 57.4%. The number of internal medicine patients was twice that of surgical patients. Elderly (>60 years) and adults (18-59 years) accounted for 59.6% and 30.8% respectively. The isolation rate in provincial capital cities was the highest, reaching 30.92%. The resistance rates of carbapenem-resistant Escherichia coli to cephalosporins, amoxicillin/clavulanic acid, piperacillin/tazobactam, and amikacin were 90.6%, 69.1%, 69.5%, and 22.2% respectively. Among the MIC50/MIC90 values, Tigecycline had the lowest value of 0.5/1 \(\mu\)g/ml, while Piperacillin and Piperacillin/tazobactam had the highest value of 128/128 \(\mu\)g/ml.

Conclusion: Clinically, carbapenem-resistant Escherichia coli mainly causes urinary and respiratory system infections in the elderly. There are significant regional differences in their distribution, and they exhibit a high resistance rate to \(\beta\)-lactam antibiotics. It is worth noting that tigecycline has lower MIC50 and MIC90 values for this type of resistant Escherichia coli.

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Published

2024-10-01

How to Cite

Wei Zhang, Zhirong Li, Na Wang, Zhicong Yang, Jia Li, Caiqing Li, … Minghua Zhan. (2024). Epidemiological Characteristics of Carbapenem-Resistant Escherichia coli Clinically Isolated from a Province in Northern China. Pharmaceutical Research: Recent Advances and Trends Vol. 7, 1–18. https://doi.org/10.9734/bpi/prrat/v7/2282

Issue

Pharmaceutical Research: Recent Advances and Trends Vol. 7

Section

Chapters