A Review on Nebivolol: Pharmacokinetic and Pharmacodynamics Approach

Abstract

Nebivolol is one of the most recent \(\beta\)-blocking agents and it has vasodilating effects which may be useful in hypertensive patients with heart disease of ischemic (restriction in blood supply) origin or with erectile dysfunction. It is a third generation, long acting and highly selective \(\beta\)1 adrenergic receptor antagonist. It has a unique action that distinguishes it from other beta blockers. It increases the release of nitric oxide (NO) which produces vasodilatation via \(\beta\)3 receptor agonism. It improves endothelial function, which delays atherosclerosis. It improves arterial compliance and reduces peripheral vascular resistance and also reduces heart rate without improving maximal exercise tolerance. These effects are beneficial in hypertension and angina pectoris.