Characteristics of Gut Microbiota and Metabolomics Associated with Disorders of Lipid Metabolism in Thyroid Cancer

Authors

  • Ganghua Lu Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
  • Xiaqing Yu Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
  • Wen Jiang Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
  • Qiong Luo Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China and Clinical Nuclear Medicine Center, Tongji University School of Medicine, Shanghai, 200072, China.
  • Junyu Tong Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China and Clinical Nuclear Medicine Center, Tongji University School of Medicine, Shanghai, 200072, China.
  • Suyun Fan Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China and Clinical Nuclear Medicine Center, Tongji University School of Medicine, Shanghai, 200072, China.
  • Li Chai Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China and Clinical Nuclear Medicine Center, Tongji University School of Medicine, Shanghai, 200072, China.
  • Dingwei Gao Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
  • Tingting Qiao Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
  • Ru Wang Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
  • Chengwen Deng Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
  • Zhongwei Lv Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China, Clinical Nuclear Medicine Center, Tongji University School of Medicine, Shanghai, 200072, China, Imaging Clinical Medical Center, Tongji University School of Medicine, Shanghai, 200072, China and Institute of Nuclear Medicine, Tongji University School of Medicine, Shanghai, 200072, China.
  • Dan Li Department of Nuclear Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510289, China.

DOI:

https://doi.org/10.9734/bpi/pramr/v4/3980C

Keywords:

Differentiated thyroid cancer, gut microbiota, metabolomics, lipid metabolism, predictive model

Abstract

The study's goal was to look into the relationship among the gut microbiota community, metabolites, and the development of differentiated thyroid cancer (TC). The components and traits of the fecal microbiota and metabolites from 50 patients with TC and 58 healthy controls(HCs) were determined using 16S rRNA gene sequencing and an integrated LC-MS-based metabolomics method.  In the TC patients, there was a significant decline in the variety and richness of the gut microbiota. The gut microbiota's makeup had undergone a considerable change, and the Bacteroides enterotype dominated it in TC patients. Furthermore, the diagnostic validity of the combined model (three genera and eight metabolites) and the metabolite model (six metabolites) for differentiating TC patients from HCs were noticeably greater than those of the microbial model (seven genera). LEfSe analysis demonstrated that genera (g_Christensenellaceae_R-7_group, g_Eubacterium_coprostanoligenes_group) and metabolites [27-hydroxycholesterol (27HC), cholesterol] closely related to lipid metabolism were greatly reduced in the TC group. In addition, a clinical serum indicator (total cholesterol) and metabolites (27HC and cholesterol) had the strongest influence on the sample distribution. Additionally, in the TC group, functional pathways involved in steroid production and lipid digestion were suppressed. 27HC was substantially correlated with microbes that were involved in metabolism in the microbiota-metabolite network (g Christensenellaceae R-7 group). Our study looked at the characteristics of TC patients' gut microbiota. The results of this study will aid in identifying risk variables that impact TC formation and incidence in the intestinal microecology.

Published

2023-01-09

How to Cite

Ganghua Lu, Xiaqing Yu, Wen Jiang, Qiong Luo, Junyu Tong, Suyun Fan, … Dan Li. (2023). Characteristics of Gut Microbiota and Metabolomics Associated with Disorders of Lipid Metabolism in Thyroid Cancer. Perspective of Recent Advances in Medical Research Vol. 4, 7–37. https://doi.org/10.9734/bpi/pramr/v4/3980C

Issue

Perspective of Recent Advances in Medical Research Vol. 4

Section

Chapters