Effect of Lactobacillus fermentum HFY03 on the Antifatigue and Antioxidation Ability of Running Exhausted Mice

Authors

  • Junxiao Zhang Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China and School of Teacher Development, Chongqing University of Education, Chongqing 400067, China.
  • Ling Chen Department of Pharmacy, Xindu District People’s Hospital of Chengdu, Chengdu, 610500 Sichuan, China.
  • Lingyan Zhang School of Continuing Education, Chongqing University of Education, Chongqing 400067, China.
  • Qiuping Chen Department of Education, Our Lady of Fatima University, Valenzuela 838, Philippines.
  • Fang Tan Department of Public Health, Our Lady of Fatima University, 838 Valenzuela, Philippines.
  • Xin Zhao Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China and b School of Teacher Development, Chongqing University of Education, Chongqing 400067, China.

DOI:

https://doi.org/10.9734/bpi/mono/978-93-5547-256-4/CH3

Keywords:

Antioxidant, running, mice, superoxide dismutase, exercise physiology

Abstract

Yak yogurt is mainly produced in Qinghai-Tibet Plateau. It is a kind of naturally fermented dairy product. It contains abundant microorganisms. Lactobacillus fermentum (LF) HFY03 is a lactic acid bacteria derived from it. Our main research content is to study the influence of LF-HFY03 on the antifatigue and antioxidation ability of running exhausted mice. We gave different doses of LF-HFY03 to mice by gavage for 4 weeks. We selected vitamin C as the positive control group, mainly to study the relationship between antioxidant capacity and fatigue resistance and LF-HFY03 in mice with running exhaustion. The results showed that LF-HFY03 and vitamin C could significantly improve the running time of mice. And with the increase in LF-HFY03 concentration, the exhaustion time of mice was also extended. LF-HFY03 can reduce the content of urea nitrogen and lactic acid and also can increase the content of free fatty acids and liver glycogen. The levels of alanine aminotransferase, serum creatine kinase, and aspartate aminotransferase in mice decreased gradually as the antioxidant peptide level of walnut albumin increased. LF-HFY03 can reduce malondialdehyde (MDA) levels in a quantification-dependent manner and can also increase catalase (CAT) and superoxide dismutase (SOD) levels. LF-HFY03 can also increase the expressions of CAT mRNA, Cu/Zn-SOD, and Mn-SOD in the liver of mice. At the same time, LF-HFY03 can also increase the expression of protein of threonine transporter 1 (AST1)/alanine/cysteine/serine, mRNA, nNOS, and eNOS. At the same time, the solution could reduce the expression of TNF-\(\alpha\), syncytin-1, and inducible nitric oxide synthase (iNOS). The results showed that LF-HFY03 has a high development and application prospect as an antifatigue probiotic nutritional supplement.

Published

2022-02-21

How to Cite

Junxiao Zhang, Ling Chen, Lingyan Zhang, Qiuping Chen, Fang Tan, & Xin Zhao. (2022). Effect of Lactobacillus fermentum HFY03 on the Antifatigue and Antioxidation Ability of Running Exhausted Mice. Probiotics and Oxidative Stress, 38–53. https://doi.org/10.9734/bpi/mono/978-93-5547-256-4/CH3

Issue

Probiotics and Oxidative Stress

Section

Content