The Preventive Effect of Lactobacillus plantarum ZS62 on DSS-Induced IBD by Regulating Oxidative Stress and the Immune Response

Authors

  • Yanni Pan Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China and Department of Food Science and Biotechnology, Cha University, Seongnam, Gyeonggi-do 13488, Republic of Korea.
  • Yujing Ning Anorectal Department of Traditional Chinese Medicine, People’s Hospital of Chongqing Banan District, Chongqing 401320, China.
  • Jing Hu Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China.
  • Zhiying Wang School of Pharmacy, Heilongjiang University of Traditional Chinese Medicine, Harbin, 150040 Heilongjiang, China.
  • Xiufeng Chen Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing 400044, China.
  • Xin Zhao Chongqing Collaborative Innovation Center for Functional Food, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food, Chongqing University of Education, Chongqing 400067, China.

DOI:

https://doi.org/10.9734/bpi/mono/978-93-5547-256-4/CH2

Keywords:

Antioxidant, Lactobacillus plantarum, immune, superoxide dismutase, mice

Abstract

In this study, we used DSS to establish an IBD mouse model to study the preventive effect of Lactobacillus plantarum (L. plantarum) ZS62 on IBD in the context of oxidative stress and the immune response. We assessed the mitigating effect of this strain on IBD mice by examining the length of and histopathological changes in the colon, determining the serum antioxidant index and the levels of inflammatory cytokines, as well as the mRNA and protein expression levels of relevant genes. The study results showed that L. plantarum ZS62 could inhibit colonic atrophy in IBD mice, reduce the degree of colonic damage, downregulate the serum levels of MDA, MPO, IL-1\(\beta\), IL-6, IL- 12, TNF-\(\alpha\), and IFN-\(\gamma\) and the relative mRNA and protein expression of IL-1\(\beta\), IL-12, TNF-\(\alpha\), COX-2, iNOS, and NF-kB p65 in mouse colon tissues, and upregulate the serum levels of CAT, T-SOD, and IL-10 and the relative mRNA and protein expression of Cu/Zn SOD, Mn SOD, GSH-Px, CAT, IL-10, and IkB-\(\alpha\) in colon tissues. In summary, L. plantarum ZS62 exhibited a good preventive effect on DSS-induced IBD by regulating oxidative stress and the immune response.

Published

2022-02-21

How to Cite

Yanni Pan, Yujing Ning, Jing Hu, Zhiying Wang, Xiufeng Chen, & Xin Zhao. (2022). The Preventive Effect of Lactobacillus plantarum ZS62 on DSS-Induced IBD by Regulating Oxidative Stress and the Immune Response. Probiotics and Oxidative Stress, 18–37. https://doi.org/10.9734/bpi/mono/978-93-5547-256-4/CH2

Issue

Probiotics and Oxidative Stress

Section

Content