Authors
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Jing Zhang
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University (BTBU), Beijing 102488, P.R. China and College of Environmental and Quality Inspection, Chongqing Chemical Industry Vocational College, Chongqing 401228, P.R. China and Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, P.R. China.
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Xiaoliang Chen
Dean's Office, Chongqing Chemical Industry Vocational College, Chongqing 401220, P.R. China.
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Jia-Le Song
Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, P.R. China and Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, P.R. China.
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Yu Qian
Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, P.R. China.
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Ruokun Yi
Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, P.R. China.
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Jianfei Mu
Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, P.R. China.
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Xin Zhao
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University (BTBU), Beijing 102488, P.R. China and Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, P.R. China.
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Zhennai Yang
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University (BTBU), Beijing 102488, P.R. China.
Keywords:
Lactobacillus plantarum CQPC07, dextran sulfate sodium, colitis, colon length, expression
Abstract
The preventive effects of Lactobacillus plantarum CQPC07 (LP) on DSS-induced male C57BL/6J mouse colitis were investigated in this study. In DSS-induced colitis mice, the results showed that LP can increase colon length and decrease the ratio of colon weight/colon length. An analysis of mouse sera revealed that LP can lower serum ET (endothelin), SP (substance P), and IL-10 (interleukin-10), increase the activity of SS (somatostatin), and VIP (vasoactive intestinal peptide), and increase the levels of IL-2.Biochemical analysis of colonic tissues from mice revealed that LP can raise GSH (glutathione) and SOD (superoxide dismutase) levels while decreasing MPO (myeloperoxidase) and MDA levels (malondialdehyde).In DSS-treated mice, a pathological tissue evaluation revealed that LP can prevent colon tissue damage. Furthermore, LP has the ability to increasenNOS (neuronal nitric oxide synthase), eNOS (endothelial nitric oxide synthase), c-Kit, SCF (stem cell factor) mRNA expression and iNOS (inducible nitric oxide synthase), IL-8, and CXCR2 (C-X-C motif chemokine receptor 2) mRNA levels in the colon tissues of colitis mice. As a result, LP has a colitis inhibitory effect; the higher the concentration, the better the impact; the effect of a high concentration of LP is close to that of sulfasalazine.
