Determining the Effect of Albendazole and Mebendazole on Hydatid Cyst of Mice

Abstract

In the present research, hydatid cysts were extracted from camel livers and lungs and protoscoleces were separated aseptically at the Tambool slaughter house. Thirty 6-week-old Swiss mice (25-30 gramme body weight males) were divided into two groups of six each: a prophylactic group was given 150 ml/kg albendazole and mebendazole was given directly after injection with 2000 protoscoleces intraperitoneally for ten days. Albendazole and Mebendazole are most frequently prescribed for treatment of intestinal nematode infections. The treated group received a dose of 300 mL/kg of albendazole and mebendazole every 4 days, separated by 2 days, for 24 days, and after 6 months of protoscoleces inoculation, the two groups, along with the control group, were sacrificed and necropsied. The findings revealed a significant difference in the development of hydatid cysts. Inside the mice, a small number of cysts were observed in the groups treated with albendazole and mebendazole compared to the control group; however, albendazole was more efficacious than mebendazole, with albendazole reaching 97 percent efficiency and mebendazole reaching nearly 50 percent efficiency. This suggests that albendazole may be the drug of choice for the treatment of hydatid cysts.