Exploring MAGE Gene Expression in Cancer: How Valuable are they in Cancer Prognosis?

Authors

  • Micaela Carolina Escalada Laboratorio de Oncología Molecular, Departamento de Química Biologica and IQUIBICEN-UBA/CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Melisa Suberbordes Laboratorio de Oncología Molecular, Departamento de Química Biologica and IQUIBICEN-UBA/CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Candela Vidal Laboratorio de Oncología Molecular, Departamento de Química Biologica and IQUIBICEN-UBA/CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Martín Monte Laboratorio de Oncología Molecular, Departamento de Química Biologica and IQUIBICEN-UBA/CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Franco Andrés Pascucci Laboratorio de Oncología Molecular, Departamento de Química Biologica and IQUIBICEN-UBA/CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.

DOI:

https://doi.org/10.9734/bpi/nramms/v4/10690F

Keywords:

Cancer testis antigen, melanoma antigen genes, chemotherapy, human chromosome, androgen response elements

Abstract

Type-I Melanoma Antigen Genes (MAGE-I) are expressed in a variety of tumor tissues and correlate with poor prognosis. At molecular level, MAGE-I proteins behave as tumor drivers by interfering with major tumor-associated signaling pathways. In this chapter we review the main oncogenic function of selected MAGE-I proteins to highlight the relevance of specific MAGE-I gene identification in human tumor samples for potential clinical interpretation.

Published

2023-10-02

How to Cite

Micaela Carolina Escalada, Melisa Suberbordes, Candela Vidal, Martín Monte, & Franco Andrés Pascucci. (2023). Exploring MAGE Gene Expression in Cancer: How Valuable are they in Cancer Prognosis?. Novel Research Aspects in Medicine and Medical Science Vol. 4, 99–107. https://doi.org/10.9734/bpi/nramms/v4/10690F

Issue

Novel Research Aspects in Medicine and Medical Science Vol. 4

Section

Chapters