Study on Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug

Authors

  • Jagan Mohana Rao Saketi Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, A.P., India.
  • S. N. Murthy Boddapati Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, A.P., India.
  • M. Raghuram Department of Botany & Microbiology, Acharya Nagarjuna University, Guntur-522510, A.P., India.
  • Syed Farooq Adil Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.
  • Mohammed Rafi Shaik Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.
  • Osamah Alduhaish Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.
  • M. Rafiq H. Siddiqui Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.
  • Hari Babu Bollikolla Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, A.P., India.

DOI:

https://doi.org/10.9734/bpi/nicst/v11/7323D

Keywords:

Pd(PPh3)4, indazole, anticancer activity, HCT-116, MDA-MB-231

Abstract

A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a-3j) and their N-methyl derivatives (5a-5j) are evaluated for in vitro anticancer activity against two cancer cell lines, HCT-116 and MDA-MB-231. The results reveal that the indazole derivatives tested display mild to moderate anticancer activities against the cell lines tested. We believe that slight structural modification of these active derivatives may yield better prospective anticancer drugs and demand further experimental investigations, especially in the area of anticancer research.

Published

2021-04-16

How to Cite

Jagan Mohana Rao Saketi, S. N. Murthy Boddapati, M. Raghuram, Syed Farooq Adil, Mohammed Rafi Shaik, Osamah Alduhaish, … Hari Babu Bollikolla. (2021). Study on Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug. New Ideas Concerning Science and Technology Vol. 11, 72–89. https://doi.org/10.9734/bpi/nicst/v11/7323D

Issue

New Ideas Concerning Science and Technology Vol. 11

Section

Chapters