Sialic Acid and Type-2 Diabetes Mellitus

Authors

  • Yendrembam Pascal Singh Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.
  • Manoj Kumar Nandkeoliar Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.
  • Ved Pal Singh Punia Department of Medicine, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.
  • Gladys Rai Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.

DOI:

https://doi.org/10.9734/bpi/nicb/v3/3887F

Keywords:

Sialic acid, type-2 diabetes mellitus, hyperglycemia

Abstract

Background: Diabetes mellitus is one of the most common metabolic illnesses characterised by chronic hyperglycemia and is linked to a higher risk of microvascular complications. Serum sialic acid has been identified as a possible risk factor for Type 2 diabetes. Serum sialic acid levels in Type-2 diabetics are frequently higher than in non-diabetic individuals.

Objectives: The objective of the study was to estimate the serum sialic acid in patients with Type 2 Diabetes Mellitus and non-diabetic individuals in NCR, Delhi and evaluating the levels of serum sialic acid with fasting blood glucose in patients with Type 2 Diabetes Mellitus and also in non-diabetic individuals.

Materials and Methods: The study, which took place in Delhi's NCR, was a cross-sectional investigation of 70 people aged 30 to 70. There were two groups of thirty-five people with type-2 diabetes mellitus (15 men and 20 females) and thirty-five people without diabetes who served as controls (16 males and 19 females).

In both groups, fasting blood glucose and serum sialic acid were determined.

Results: Serum sialic acid levels were found to be higher in type 2 diabetes mellitus (76.60±7.89) compared to non-diabetics (39.66±9.55) with a statistically significant p-value of <0.001.

Conclusion: According to the findings of this study, serum sialic levels were found to be higher in Type 2 diabetes patients in Delhi-NCR, indicating that these patients were at risk of developing microvascular problems. As a result, determining sialic acid levels may aid in the early detection and prevention of microvascular problems associated with type 2 diabetes.

Published

2021-09-25

How to Cite

Yendrembam Pascal Singh, Manoj Kumar Nandkeoliar, Ved Pal Singh Punia, & Gladys Rai. (2021). Sialic Acid and Type-2 Diabetes Mellitus. New Innovations in Chemistry and Biochemistry Vol. 3, 8–16. https://doi.org/10.9734/bpi/nicb/v3/3887F

Issue

New Innovations in Chemistry and Biochemistry Vol. 3

Section

Chapters