Understanding Pelger Huët Cell

Abstract

The Pelger-Huët anomaly (PHA), an autosomal dominant condition is characterized by morphologically abnormal neutrophil. This abnormal neutrophil has an unique morphological appearance called as Pelger-Heut cell (PHC) .Understanding  this special type of cell is essential as it demands a diagnostic challenge to differentiate it from its mimickers. This article summarises the history of PHA, pathogenesis, and guidance for distinguishing between congenital and acquired PHA, as well as their various morphological variants. We present an intriguing case of pseudo-PHA in a 70-year-old male with Leptospirosis who had spectrum of dysplastic neutrophils with unilobed, unilobed intended, and bilobed pelgeroid cells in the peripheral smear.