Statins Enhances Anti-Androgen Abiraterone Acetate Therapeutic Efficacy on Castration-Resistant Prostate Cancer Cells

Authors

  • Dannah R. Miller Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Matthew A. Ingersoll Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Yu-wei Chou Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Ming-Fong Lin Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA and Section of Urological Surgery, School of Medicine, University of Nebraska Medical Center, Omaha, NE, USA and Eppley Institute for Cancer Research, University of Nebraska, Medical Center, Omaha, NE, USA and College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.

DOI:

https://doi.org/10.9734/bpi/nhmmr/v2/2714C

Keywords:

Castration-resistant prostate cancer, statins, anti-androgens, combination treatments, prostate cancer

Abstract

Castration-resistant (CR) prostate cancer (PCa) treatment options are limited. A substantial sub-population of CR PCa tumors can synthesize androgens for intracrine androgen receptor (AR) activation, inhibiting androgen biosynthesis could be an effective treatment option for these patients.

Study Objective: The androgen biosynthesis inhibitors simvastatin, atorvastatin, and ketoconazole were found to directly inhibit growth, migration, and colony formation of androgen-independent LNCaP C-81 cells that exhibit de novo androgen biosynthesis, with simvastatin being the most effective. Importantly, statins specifically enhanced growth suppression in combination with anti-androgen abiraterone acetate effects on CR PCa cells.

Conclusion: Statins can be combined with abiraterone acetate to improve anti-androgen therapy for CR PCa.

Published

2022-03-08

How to Cite

Dannah R. Miller, Matthew A. Ingersoll, Yu-wei Chou, & Ming-Fong Lin. (2022). Statins Enhances Anti-Androgen Abiraterone Acetate Therapeutic Efficacy on Castration-Resistant Prostate Cancer Cells. New Horizons in Medicine and Medical Research Vol. 2, 108–126. https://doi.org/10.9734/bpi/nhmmr/v2/2714C

Issue

New Horizons in Medicine and Medical Research Vol. 2

Section

Chapters