An Experimental Rat Model of Acute Pancreatitis and the Effect of Apigenin
New Horizons in Medicine and Medical Research Vol. 11,
10 June 2022
,
Page 103-118
https://doi.org/10.9734/bpi/nhmmr/v11/6125F
Abstract
The aim of the study was to investigate the effect of apigenin (AP) on acute pancreatitis (ACP) by measuring the values of interleukin-6 (IL-6), interleukin-18 (IL-18) and resistin (R) in serum and CD45 as well as high mobility group box 1 protein (HMGB1) in intestinal tissue using a rat experimental model. 126 male Wistar rats were used, divided in three groups: Sham (S), Control (C) and Apigenin (Ap). The S group underwent laparotomy and closure of the abdominal wall. The C group underwent ligation of the pancreatic duct to induce acute pancreatitis. The apigenin group after induction of ACP, received AP. Blood and intestinal tissue were collected. Following AP administration, IL-6 and IL-18 in serum decreased as well as HMGB1 and CD45 in intestinal tissue. In contrast R remained at low levels in the Ap group. In a bilio-pancreatic duct ligation experimental model of ACP, AP treatment appears to protect intestinal and serum parameters, lowering the severity of ACP. As a result, giving this substance to humans could reduce the damage to the organs affected in the early stages of ACP.
- Apigenin
- rat
- HMGB1
- interleukin-6
- interleukin-18
- pancreatitis
- resistin